Activation of macrophage TLR4 by bacterial endotoxins is important for the progression of sepsis, but the underlying ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback.
MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...
A machine-learning method predicts whether a genetic variant is pathogenic and affects certain human tissues. The ...
K Heran Darwin is at New York University Grossman School of Medicine and a regular columnist for EMBO reports.
Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...
Human papillomavirus (HPV) and hyperactivated YAP1 form a YAP1-HPV oncogenic alliance to drive the malignant transformation ...
It is boomtime for metabolism and metabolomics research. One hundred years after Otto Warburg put metabolism at the core of ...
Co-expressing NPY and its inhibitory receptor Y2 in excitatory hippocampal cells allows inhibitory autoregulation of ...
FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...
ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer
The inhibition of ERK5 is a potential complementary strategy for countering FAK inhibitor resistance in patients with lung ...
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