The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Christian McCaffrey on Wednesday shared his first message to his fans after suffering a season-ending injury on Sunday.

Having suffered a knee injury that landed him on injured reserve during a snowy loss to the Bills on Sunday night, 49ers ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...

San Francisco 49ers running back Christian McCaffrey made his season debut less than one month ... shared his initial ...

McCaffrey's post garnered all sorts of reactions from fans and NFL personalities alike. One that stood out, however, is his wife Olivia Culpo's five-word message for her husband, who is clearly going ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...

Slow motion video shows where 49ers running back Christian McCaffrey seemingly injured himself and ended his season.