The first female White House chief of staff is a longtime Florida operative and onetime aide to moderate Republicans who is “more about strategy than ideology.”

Ms. Wiles, a principal architect of Donald J. Trump’s 2024 presidential campaign, will become the first woman to hold the job.

After helping engineer Donald Trump’s improbable and sweeping victory in the presidential race, Susie Wiles, the president-elect’s unassuming co-campaign chief, is seen as the frontrunner to become his White House chief of staff, according to six sources familiar with discussions inside the campaign.