Objective Verinurad (RDEA3170) is a high-affinity, selective URAT1 inhibitor in development for treating gout and asymptomatic hyperuricaemia. This study evaluated the pharmacodynamics, ...

Osteoporosis (ie, low bone mineral density) is common in ankylosing spondylitis, related to both systemic inflammation and decreased mobility. Vertebral fracture risk is increased; acute back pain in ...

Objectives This meta-analysis investigated the frequency of ocular involvement in childhood and adult spondyloarthritis (SpA). Methods A systematic review of the literature was conducted. Medline, Web ...

Polymyalgia rheumatica (PMR) is a rheumatic disease characterised by inflammatory pain and stiffness in the neck, shoulders and pelvic girdles. Recently, interspinous bursitis at the cervical and ...

Takayasu arteritis (TAK) is an idiopathic large vessel vasculitis, which occurs most commonly in women of reproductive age. During pregnancy, TAK is associated with adverse pregnancy outcomes, ...

Background The DNA of rheumatoid arthritis synovial fibroblasts (RASF) is globally hypomethylated; this contributes to an aggressive behaviour. In an attempt to remethylate these cells, we ...